Firm, resilient, youthful skin is always in, but there are many processes at play that can sabotage even our best efforts towards this goal. One process is glycation, in fact glycation is one of the major contributing factors to collagen breakdown and sagging skin. Fortunately, aesthetic professionals know about combating glycation and preserving a youthful looking skin.
Glycation is a chemical process in which sugar attaches to a protein, damaging collagen and leading to visible signs of ageing. Collagen is found in our joints, blood vessels, eyes and especially the skin. It is best known for giving the skin its firmness, resilience and elasticity. When a collagen protein becomes glycated the sugar attachment makes the protein stiff, damaging the collagen. meaning that it can no longer perform its normal function and will eventually breakdown.
Since the body is eager to remove and replace any damaged tissue, it tries to make quick work of clearing out these damaged proteins. To do so, a special enzyme called collagenase digests collagen so it can be reabsorbed by the body. When collagenase is activated, it does not always differentiate between damaged and healthy collagen – so healthy collagen is sometimes digested as well. Like inflammation and many other processes in the body, this breakdown is necessary and helpful in moderation, but can be damaging when excessive.
To heal the damage from glycation and collagenase, fibroblasts are called upon to restore and replace collagen. Fibroblasts are cells found in the dermis that create collagen, elastin, and ground substance. Ground Substance is a jelly like mixture made mainly of glycosaminoglycans that create a supportive framework for skin cells, collagen, and elastin fibers. When collagen is damaged and cleared by collagenase, fibroblasts are activated and begin to make more collagen. New collagen is laid down where the old collagen was destroyed, and the skin regains its youthful support.
One of the best ways to slow the effects of aging is to prevent glycation and support the body’s collagen synthesis. Thankfully, certain cosmeceuticals can help to maintain the skin’s youthful appearance by slowing the process of glycation and supporting the body’s collagen production.
In one experiment to test the effects of cosmeceuticals on collagen synthesis, two small incisions were made on a participant’s skin, then sewn closed. Stitches were removed in one week, and Super Serum Advance+ was applied to one of these incisions twice per day for three months, then once per day for the next three months. The control incision was left to heal without help from any products. In comparing the incisions throughout their healing process, the incision that was left untreated remained red and had more visible scar tissue. The incision that was treated with Super Serum Advance+ looked nearly normal, with no visible scar tissue or hyperpigmentation. These results indicate that properly chosen collagen-boosting cosmeceuticals are effective in restoring the skin’s ability to repair.
Another study measured the ability of fibroblasts to make collagen over a three-day period. Two sets of 55-year-old fibroblasts were tested: one with no product use (control) and one with product use (Youth Complex). After three days, the untreated skin maintained a low level of fibroblast activity, while the treated skins collagen sky-rocketed during all three days. The results. The results of these two studies clearly indicate the quality of collagen-boosting cosmeceuticals can play an incredible role in enhancing skin healthy through collagen synthesis.
Understanding glycation and collagen synthesis is essential for strategically fighting the aging process. As leaders in antiaging techniques and aesthetics professionals can use this science to our advantage. By recognizing how glycation affects the skin and how cosmeceuticals can reverse and prevent this damage, we can help our clients to bounce back fast and maintain their youth